[lubuntu] VirtualBox Vs Wine - Process

I definitely understand the difference between the two, however, what would be a good process to decide what program to run where? Should the first priority be Wine and if that doesn't work use a Virtual Machine?

I want to completely switch over but to Ubuntu but there are a few things I will need: Adobe CS6 / MS Office '13 / and EVE Online (game).

Just looking for any insight and experience from other users. What is the best possible scenario for running a windows program in Ubuntu?